Freshman receiver Kenny Stills also hauled in a 59-yard score earlier in the quarter.
The Sooners, a week after getting shut out in the first half in a loss to Texas A&M, look like they've found a groove again.
That, and Senior Day at Owen Field has taken on a decidedly youthful flavor, though senior running back DeMarco Murray, the program's all-time leader in touchdowns, caught a 12-yard touchdown pass to open the scoring.
Receiver Ryan Broyles also became the program's all-time leader in receptions with 222 early in the game.
Texas Tech rebounded from a 17-7 deficit to beat Missouri a week ago, but that was at home. Owen Field has not been friendly to the Red Raiders, especially of late. Ranked No. 2 the last time they came to Norman, Texas Tech left with a 44-point loss to the Sooners.
With Texas Tech's fast-paced offense, a comeback on its own wouldn't be shocking, but it coming in Norman, where Oklahoma looks on its way to a 36th consecutive home win, would certainly be.