The source added that Book is expected to be available for the No. 3 Fighting Irish's game against No. 13 Syracuse on Nov. 17.
Coach Brian Kelly said on Thursday that Book is day to day with an upper-body injury, but did not address Book's status for Saturday's game.
Kelly said Brandon Wimbush has received the bulk of reps in practice but Kelly also said "we can win if [freshman] Phil [Jurkovic] has to play." Kelly also said Book has been at practice but did not say what he has been doing there.
Book suffered the rib injury in last Saturday's 31-21 victory over Northwestern. He finished the game.
Book has played a big role in Notre Dame's 9-0 record after taking over as the starting quarterback against Wake Forest on Sept. 22. He replaced starter Wimbush, who in the first three games of the season threw for one touchdown and four interceptions while completing 55.3 percent of his passes.
Book completed all three of his passes in the fourth quarter against Vanderbilt, was named the starter for the following game against Wake Forest and has held on to the job ever since. His presence in the Notre Dame offense has given the Irish a much-needed lift, with Book throwing 15 touchdowns and four interceptions in the seven games he has seen action.
With the injury expected to sideline Book for only one game, Wimbush will lead the offense against a Florida State defense that ranks 65th overall in yards allowed per game and 121st in passing yards allowed per game.
Irish Sports Daily first reported that Book would not play against the Seminoles.
ESPN's Adam Rittenberg and Tom VanHaaren contributed to this report.