Wade, the preseason Big 12 player of the year, reported the discomfort to medical staff after scoring 11 points in Saturday's 68-53 victory Oklahoma, according to the school.
"I have got to see how Dean is," Weber told reporters Saturday night. "That will be the determining factor. Every day I kind of hope and pray that we have been able to practice a little bit. You can see we are a little better. Dean is a little better, moving better. I have got to protect them and their future. Obviously, we want to be ready for the NCAA tournament."
Wade has been dealing with foot issues. He missed several weeks earlier this season with a right foot injury.
Wade is averaging 12.9 points, 6.2 rebounds and 2.8 assists for the Wildcats (24-7).