NFL Insiders predict: Week 2 upsets, fantasy flops, sleepers, more

Chiefs' big-play ability for real under Mahomes (1:50)

Ryan Clark and Jeff Saturday react to Patrick Mahomes' four-touchdown effort in the Chiefs' 38-28 win over the Chargers. (1:50)

Our panel of NFL Insiders predict Week 2's biggest upsets, fantasy flops and potential sleepers.

Plus: biggest areas of concern after one week, where Le'Veon Bell will suit up in 2019 and which personal predictions we're calling back after seeing each team play.

What's your top upset pick for Week 2?

Mike Clay, NFL writer: Lions (+5.5) over 49ers. Yes, the Lions got smoked at home by the Jets, and Matthew Stafford is beaten up, but Detroit's offense is still one of the league's best. The 49ers figure to look better back home, tasked with one of the league's worst defenses. But considering their own holes on defense, this could be a shootout, and I wouldn't be surprised if Stafford rebounds in a big way.