Florida Highway Patrol Lt. Alex Camacho said the Ford F250 driven by the 22-year-old Norton crashed into a concrete barrier on State Road 836 near Miami. The truck overturned and came to a rest on its roof.
Miami-Dade Fire Rescue crews rendered aid to Norton, who had severe injuries to his left arm and was transported to Jackson Memorial Hospital's Ryder Trauma Center, where he remains.
"With sadness, I can confirm that Kendrick Norton was in a car accident last night and suffered multiple injuries, including the amputation of his arm," his agent Malki Kawa tweeted. "We ask that you continue to pray for him."
His medical status is not considered life-threatening.
"We were made aware this morning of a serious car accident involving Kendrick Norton," the Dolphins said in a statement Thursday. "Our thoughts and prayers are with Kendrick and his family during this time."
The Florida Highway Patrol said a second vehicle was involved in the crash and that the driver of the 2015 Maserati did not sustain any injuries.
Norton's coach at the University of Miami, Manny Diaz, sent out his prayers on Twitter on Thursday morning.
The U family is praying for Kendrick, his family and the medical professionals helping him this morning. 🙏🏽🙏🏽🙏🏽 https://t.co/uYgXANF5H0— Manny Diaz (@Coach_MannyDiaz) July 4, 2019
Norton was selected in the seventh round of the 2018 NFL draft by the Carolina Panthers, and the Dolphins signed him off the Panthers' practice squad in December. He was expected to compete for a spot on the 53-man roster this season.
The Associated Press contributed to this report.