Hilton appeared to aggravate his quad injury after catching a 4-yard touchdown pass in the end zone closest to the Colts locker room in the final seconds of the first half. He immediately went to the locker room after the play. Hilton returned to the sideline without his helmet and gloves with about 11 minutes left in the third quarter.
However, Hilton said he actually aggravated the injury "a couple of plays before" the touchdown.
"I kind of reinjured it. I kind of felt it. I wanted to keep playing because I knew I wouldn't be able to come out in the second half," he said.
The Colts' top receiver had been questionable for Sunday's game after being a limited participant in practice all week due to the quad injury. He left the game with eight receptions for 65 yards and the touchdown.
"Came back in and the doctor's examined it," Hilton said. "Wasn't no need for me to go back out there and probably tear it."
Losing Hilton meant the Colts were without their best offensive player and defensive player, as linebacker Darius Leonard missed Sunday's game with a concussion suffered against the Tennessee Titans on Sept. 15.
Defensive lineman Tyquan Lewis has also been ruled out after suffering an ankle injury.