Paris Saint-Germain and Brazil forward Neymar will be out of action for four weeks because of a thigh injury, the Ligue 1 leaders announced on Monday.
"Neymar underwent an MRI [scan] this afternoon... a medical check up will be done in eight days but his return to competition is expected in four weeks depending on the evolution [of the injury]," PSG said in a statement.
The striker is set to miss PSG's two Champions League games against Club Brugge next week and on Nov. 6. He'd already missed PSG's first two UCL games due to a suspension incurred last season.
Neymar picked up the injury during Brazil's 1-1 draw against Nigeria in a friendly game in Singapore on Sunday.
National team coach Tite on Sunday defended his use of Neymar in the Nigeria friendly in which the former Barca man limped off after 12 minutes with an injury.
The latest medical setback for Neymar is the third he has suffered while on national team duty in the last year, and comes as he was gaining his club form with PSG.
When asked about Neymar's injury after the match in Singapore on Sunday, Tite said his No. 10 was "not at all" an injury risk.
Was it a mistake for Brazil to start Neymar?
Gab Marcotti looks at how PSG will be impacted by Neymar's injury he picked up playing for Brazil.
"It would be irresponsible and incompetent of me [to play him if he was a doubt]," Tite said. "I would have to receive the complaints of the coach and the president of PSG if that happened."
Neymar, who made his 101st appearance for the national team, touched the back of his left thigh as he left the pitch and was replaced by Philippe Coutinho.
A team spokesman said Neymar "felt discomfort," while Globoesporte.com cited the Brazilian team doctor as saying the player didn't feel much pain.
Neymar was at the centre of an acriminous transfer saga with PSG and former club Barcelona this summer, which led to tensions with the player, the French champions' front office, and their supporters.
He has scored four times in five league matches as PSG entered the international break atop the Ligue 1 table.
The draw extended Brazil's winless run to four games. Since lifting the Copa America in July, Brazil have also drawn with Colombia and Senegal and lost to Peru.
Nicol: Neymar's lack of class overshadows 100-cap milestone
Steve Nicol explains why Neymar isn't one of Brazil's top five players of all time following his 100th cap.
Reuters contributed to this report.