UConn is once again the heavy favorite -- but what obstacles might await?

Geno 'never envisioned' this year's Huskies so successful (1:58)

Geno Auriemma talks about how the fear of breaking UConn's 107-game win streak can affect players' mindsets and praises his three key players: Gabby Williams, Katie Lou Samuelson and Napheesa Collier. (1:58)

With every other team in the NCAA tournament, the question is: What does it have to do to win the title?

With UConn, though, it's this: What do the Huskies have to do to lose it?

UConn is the No. 1 overall seed. The Huskies are going for their fifth consecutive -- and 12th overall -- national championship. They play the early rounds at home in Gampel Pavilion in Storrs, Connecticut.

If they advance to the regional, it's about 80 miles southwest, in Bridgeport. The regional was there last year, too, and the Huskies clobbered Mississippi State and Texas in the regional semifinals and final.

So there is nothing but familiarity for UConn on the road to the Women's Final Four in Dallas, one of the few cities left in the United States where the Huskies haven't raised a national championship trophy.

All right, we're exaggerating, but they have won so much that it seems that way.

So, has it all become too easy for the Huskies? It might appear that way from the outside. But it takes a lot of work to look this good for this long. The Huskies ended up in what, to be frank, is not a very challenging women's basketball league after the Big East broke up and changed for 2013-14.

UConn has not lost a single game to a league foe since the formation of the American Athletic Conference. Yet that hasn't made the Huskies any less sharp. You can attribute that to the competitive fire the UConn staff is able to instill and keep stoked no matter the opponent.

UConn lost superstar Breanna Stewart -- the Final Four's most outstanding player a record four years in a row -- and her talented cohorts Moriah Jefferson and Morgan Tuck as the first three picks in the WNBA draft last spring.

But that just meant a new "big three" -- sophomores Katie Lou Samuelson and Napheesa Collier and junior Gabby Williams -- has taken over. Coach Geno Auriemma insisted in the preseason that he wasn't sure how the Huskies would respond to their supposed leadership gap, especially since they had a challenging nonconference schedule.

But the Huskies have run their winning streak to 107 consecutive games. We've seen this movie before; to say UConn "doesn't rebuild, it reloads" doesn't quite do justice to how well the Huskies maintain their culture.

Admittedly, along the way the Huskies have had a few scares: a two-point win over Florida State in the season opener, a six-point win at Maryland in December, a surprisingly tough three-point win at Tulane in February. That last game mentioned was probably just what Auriemma wanted: something to shake up the Huskies a little and bring their focus even tighter.

Since then, the Huskies have been back to their untouchable selves. So, as we asked at the start, what could lead to UConn losing? The Huskies virtually never beat themselves, so it's going to take an opponent having a very, very good game.

The Huskies could face an annoyed Syracuse team in the second round; the Orange can't be happy with their No. 8 seed or their placement. Last year, these teams met in the national championship game, won 82-51 by UConn.

Still, the odds of the Huskies losing at home are pretty close to zero. So we move to the Bridgeport Regional, and this is where it could get interesting. Maybe.

If seeds hold, UConn would face UCLA in the Sweet 16. The Bruins were fourth in the Pac-12 this year, and they had their big moments, including victories against Oregon State, Stanford and Washington -- although they also lost once to the Huskies and twice to the Beavers.

Guard Jordin Canada and forward Monique Billings are both standout juniors for the Bruins. But does UCLA have enough to challenge UConn, especially in Bridgeport? Probably not.

The other regional semifinal there, though, could be quite a grudge match, again, that's if seeds hold. No. 2 Duke is led by guard Lexie Brown, who transferred from Maryland, which is the No. 3 seed. The Blue Devils are aching to show they are truly "back" after missing the NCAA field last year. The Terps want to prove they were underseeded and undervalued after tying for the Big Ten regular-season title and winning the conference tournament.

Maryland beat Duke in overtime in the 2006 NCAA final, one of the best championship games in women's tournament history. Their subsequent ACC rivalry got even more heated after that, and continued until the Terps left for the Big Ten.

You've got to figure UConn fans will be rooting for Duke, big-time, if the Blue Devils face Maryland. The Terps, led by seniors Brionna Jones and Shatori Walker-Kimbrough, gave UConn a good battle back in December before falling 87-81.

Meanwhile, Duke hasn't given UConn a good battle in more than a decade. The Blue Devils, under then-coach Gail Goestenkors, beat the Huskies 63-61 in overtime in the 2006 Elite Eight in Bridgeport.

But in UConn's eight subsequent meetings with Duke -- between 2007 and 2014, all with Joanne P. McCallie as the Blue Devils coach -- the Huskies have won by an average of 28.6 points.

If UConn gets through Bridgeport and makes it to Dallas, then what might be the obstacles? Baylor actually played UConn well for much of their Nov. 17 meeting in Storrs; the score was tied 54-54 with 7:29 left. Then UConn took off, outscoring Baylor 16-2, and that was that. The Huskies won 72-61.

The Lady Bears have considerable size, led by 6-foot-7 Kalani Brown, and a lot of depth -- with or without senior guard Alexis Jones. But Baylor will be a tougher team to beat if Jones, who has a bone bruise, is able to play.

The other No. 1 seeds also lost this season to UConn: Notre Dame fell 72-61 at home in December, and South Carolina lost 66-55 at Storrs in February.

Of course, it might not be all No. 1 seeds in Dallas. Last year, UConn was the only top seed that made it to the Final Four.

But no matter how you predict it, the Huskies still come out as big, big favorites. Maybe not as big as last year, when it seemed inconceivable they could be beat. But they've kept their winning ways going and don't look as if they have any intention of stopping.